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KMID : 0043320080310010010
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Archives of Pharmacal Research
2008 Volume.31 No. 1 p.10 ~ p.16
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Phytochemical Investigation of Tiarella polyphylla
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Shen Guanghai
Lee Hyeong-Kyu
Min Byung-Sun
Lee Joong-Ku
Kim Young-Ho
Oh Sei-Ryang
Ahn Kyung-Seop
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Abstract
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Seven flavonoids (1-7), two triterpenoids (8 and 9) and four steroids (10, 11, 12 and 13) were isolated from the whole plant of Tiarella polyphylla. Based on the physicochemical and spectroscopic analyses, their structures were identified as myricetin (1), astragalin (2), afzelin (3), quercitrin (4), myricitin (5), nicotiflorin (6), isoquercitrin (7), tiarellic acid (8),3β-hydrory-20 (29)lupen-27-oic acid (9),β-sitosterol-3-o-β-glucoside (10), stigmasterol-3-O- β-D-glucoside(11),β-sitosterol (12) and ergosterol endoperoxide (13). All 13 compounds, with the exception of tiarellic acid were isolated for the first time from T. polyphylla. In the anti-complementary assay, the steroids (12 and 13) exhibited potent activities; whereas, the flavonoids (1 to 7) showed weak or no activities, but even the triterpenoids (8 and 9) and steroidal saponins (10 and 11) evoked hemolysis.
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KEYWORD
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Tiarella polyphylla, Saxifragaceae, Flavonoids, Triterpenoids, Steroids, Anti-complementary activity
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